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Kynoselen

Kynoselen was one of those weird quasi-legal, grey market drugs that used in horse racing that its way into the anabolic arsenal of many athletes and bodybuilders. I will be frank and say that its effects are generally more profound in those who are already reasonably lean and muscular. I've noticed, through my research, that the biggest mitigating factor in this stuff's use is that its not doing much (cosmetically) for those whose bodyfat is too far over 12%. Over 15% and I'd go so far as to say kynoselen is a waste. Its fat burning properties are felt proportionately with how lean you already are. It will help with vascularity if you're lean also. Women seem to be much bigger proponents of this stuff than men, generally, but that's probably because they tend to aim for comparatively less gains than men, and thus are much more satisfied with a few lean pounds or a few solid strength increases. Again, on a lean 125lb female, 5lbs of lean mass is very noticeablemuch more so than on a male twice that size.
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Let's unpack a bottle of Kynoselen and see what's in it:
 
  • AMP (adenosine monophosphate) is what I'd consider to be the primary active ingredient of Kynoselen. This is a source of phosphorous. It combines with 2 phosphate atoms to become ATP (adenosine triphosphate), which provides an immediate source of cellular energy. AMP aids lipolysis (1), or fat-burning, and its probably the inclusion of this ingredient that makes Kynoselen's effects in this area the most profound. It also has the ability to convert to ATP, or adenosine tri-phosphate. ATP is the primary carrier of energy within cells, and most cells die quickly in the absence of it. ATP in turn powers muscles. This is probably why users of Kynoselen report an increase in "energy levels."
  • Magnesium aspartate has a major role in muscle contraction (5)(6), and this is why it's in high demand with many strength athletes. When Dan Duchaine made his supplement recommendations nearly a decade ago in Muscle Media, this was on the list. Magnesium also activates enzymes necessary for the metabolism of carbohydrates and amino acids, which leads to protein synthesis.
  • Heptaminol is also included in this preparation. It aids in dilation of coronary blood vessels and could thereby act as a sort of transport aid for oxygenated blood (4). I'm sure this is partly why it's given to race horses as a kind of "wellness tonic."
  • Cyanocobalamin (vitamin b-12) has been included in Kynoselen, and bodybuilders and other athletes have known about this substance's role in increasing energy and appetite stimulation. A deficiency in this vitamin leads to anemia, so it's always a good idea to include it in your diet. The injectable version is also very popular.
  • Selenium is an anti-oxidant, and has been used as a protective agent in spinal cord injuries. I would imagine that keeping racehorses free from injury would be very important to their owners; hence its inclusion in this preparation.
  • Potassium aspartate: Mainly, we know that potassium keeps you from cramping, and again, since we are examining a compound given to racehorses, it's logical to assume that a smart breeder/owner would like to prevent his horse from cramping when millions of dollars are on the line in a race. Potassium also assists in many cardiac functions, and will probably act synergistically with magnesium to aid in muscle contractions (7).
    Looking over the ingredients of Kynoselen, it's easy to see why it's used for horse racing, and I think its similar use in athletics is pretty obvious. Sprinters and strength athletes would greatly benefit from its various energy producing substrates, as well as the ingredients added to increase contractile strength in skeletal muscle. I have heard about some pretty decent increases in strength from the sole use of this compound, and certainly it has found its way into many powerlifters' cycles.

    For bodybuilders, its benefits are pretty different. It seems to be most widely used for PCT, when it can be used in conjunction with our SERMs and AI's to hold onto gains by increasing our ability to continue using the weights that got us to the size we were while on anabolics.

    Kynoselen comes as a 100ml multi-use vial. Typically, athletes and bodybuilders pay $50-$75 for it, and inject between 1-3mls per day. The only complaint I've heard about it is that it's painful to inject it, so I would recommend injecting it with an equal amount of b-12.



    References:

    1. Extracellular cyclic AMP-adenosine pathway in isolated adipocytes and adipose tissue. Obes Res. 2005 Jun;13(6):974-81.
    2. Effect of prolonged anaerobiosis on 125I-insulin binding to rat soleus muscle: permissive effect of ATP. Am J Physiol Gastrointest Liver Physiol, Dec 1978; 235: 606 - 613.
    3. Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue. FASEB J. 2000 Sep;14(12):1793-800.
    4. [Heptaminol hydrochloride as an epithelium transporter] Can J Physiol Pharmacol. 1990 Jul;68(7):791-9. French.
    5. CaATP as a substrate to investigate the myosin lever arm hypothesis of force generation. Biophys J. 2000 Mar;78(3):1474-81.
    6. Effects of osmolality and ionic strength on the mechanism of Ca2+ release in skinned skeletal muscle fibers of the toad.J Physiol. 1993 May;464:629-48.
    7. Decreased muscle strength and contents of Mg and Na,K-pumps in chronic alcoholics occur independently of liver cirrhosis.J Intern Med. 2003 Mar;253(3):359-66.

     


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