User Menu


spacer image
Steroid Laws
 
Steroid Profiles
steroids
 
  Share
Search
Archive
From:
To:
Steroid Side Effects / All Categories

Elevated testosterone kills nerve cells

Elevated testosterone kills nerve cells

09/26/06

New Haven, Conn.--A Yale School of Medicine study shows for the first time that a high level of testosterone, such as that caused by the use of steroids to increase muscle mass or for replacement therapy, can lead to a catastrophic loss of brain cells.

Taking large doses of androgens, or steroids, is known to cause hyperexcitability, a highly aggressive nature, and suicidal tendencies. These behavioral changes could be evidence of alterations in neuronal function caused by the steroids, said the senior author, Barbara Ehrlich, professor of pharmacology and physiology.

"Next time a muscle-bound guy in a sports car cuts you off on the highway, don't get mad, just take a deep breath and realize that it might not be his fault," said Ehrlich.

Testosterone is the main male hormone and it plays fundamental roles in development, differentiation, and cellular growth. In neurons, testosterone acts as a neurosteroid and can induce changes at the cellular level, which in turn lead to changes in behavior, mood and memory. Both neuroprotective and neurodegenerative effects of androgens have been reported.

The researchers showed that high levels of testosterone triggered programmed cell death in nerve cells in culture. Cell death, or apoptosis, is critical in many life processes, including development and disease. It is characterized by membrane instability, activation of caspases, which are the executioner proteins in apoptosis, change in membrane potential, and DNA fragmentation.

"In the present study we have demonstrated for the first time that the treatment of neuroblastoma cells with elevated concentrations of testosterone for relatively short periods, six to 12 hours, induces a decrease in cell viability by activation of a cell death program," Ehrlich said. "Low concentrations of testosterone had no effects on cell viability, whereas at high concentrations the cell viability decreased with incremental increases in hormone concentration."

The testosterone-induced apoptosis described in this study occurs through overactivation of intracellular Ca2 signaling pathways. Overstimulation of the apoptotic program in neurons has been associated with several neurological illnesses, such as Alzheimer disease and Huntington disease.

 



 

© 2000-2024 Steroid.com By viewing this page you agree and understand our Privacy Policy and Disclaimer. return to top of page
Anabolic Steroids
 
Anabolic Review