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Nandrolone Phenylpropionate

Nandrolone Phenylpropionate
Nandrolone Phenylpropionate


Libriol and Tribolan are trade names for Nandrolone Phenylpropionate, another exotic anabolic preparation coming out of an Australian company, RWR, which is shrouded in mystery. Anabolic NA is Syd Group's entry into this bizarre combination of steroids. They all seem to be of popular demand in bodybuilding circles primarily because of this mystique. I will look at the pros and cons of this obscure drug, Nandrolone Phenylpropionate, and if it qualifies to be in the muscle building, fat-melting cycles of our future.

Testosterone

Libriol is an injectable veterinary product containing short esters of the drugs nandrolone and methandriol. Anabolic NA has the rare Nandrolone Cypionate, and Tribolan contains the very long estered Nandrolone Decanoate. Steroid.com members should immediately recognize the first drug, nandrolone. A steroid derived from modifying the testosterone molecule, Nandrolone is one of the most popular drugs in the world and with good reason; it is a versatile steroid that can be used in "bulking" or "cutting" cycles. Nandrolone has many benefits for athletes coupled with an unbeaten safety record. It has an anabolic (muscle building) rating of 125, making it an excellent drug for adding lean muscle. Neither is it very androgenic (leading to the development of male characteristics), with an androgenic ratio of only 37. Nandrolone aids the hardcore athlete in various ways: it promotes nitrogen retention in the muscle cell (1), which in turn promotes the muscle cell to synthesize and store more protein; it increases levels of the highly anabolic hormone IGF-1 in muscle tissue (2); and it leads to a significant increase in the amount of androgen receptors in muscle (3). Nandrolone has been proven to improve endurance (4), increase the number of red blood cells (5) and speed the rate of glycogen replenishment after strenuous physical activity (6). One trait Steroid.com members love about nandrolone is its ability to reduce joint pain and soreness (7)this is because the drug increases the rate of collagen synthesis and increase bone mineral content (8)(9). Shown to be a good drug for fat loss (10), nandrolone can reduce the amount of fat under the skin and around the abdominal area (10). The amount lost, however, is dependant on dose, with higher dosages having the greatest overall effect (11). Nandrolone also has positive effects on the brain. It increases chemicals in the brain that promote aggressive behavior, which can improve both speed and power (12). Nandrolone aromatizes (convents to estrogen) slightly, but only at about 20% the rate of testosterone, so estrogenic side effects such as breast tissue growth in men (gynecomastia), fat gain and water retention are not major issues. Steriod.com members who use nandrolone seldom complain of androgenic side effects such as prostate enlargement, loss of hair and acne. Those who are worried about their cardio vascular health can use nandrolone without fear; studies have shown that it does not negatively affect cholesterol (13). The ester of nandrolone contained in Libriol is the phenylpropionate ester, which provides a rapid, high concentration of hormone in the blood steadily for up to four days.

Nandrolone Phenylpropionate is a good drug, but it is not perfect. With its chemical structure it acts directly on the receptor of the female sex hormone progesterone with a binding rate of 20% of the actual hormone (14). Despite its low aromatizing rate, this can lead to breast growth in gyno-prone individuals. There is no need for panic though, because the drugs letrozole (femera) or fulvestrant can easily combat this (15) reaction. Elevated prolactin levels are also a side effect of nandrolone usage, but there are readily available drugs like bromocriptine and cabergoline that activate the dopamine receptor to lower prolactin levels (5). Shrunken balls (testicular atrophy) may be a problem from elevated prolactin as well; HCG (female hormone that acts like LH when introduced into the male body) used during the cycle can possibly remedy or prevent the condition (16). Probably the worst effect Nandrolone Phenylpropionate has is on natural testosterone production: a single 100mg dose of nandrolone causes complete nullification of testosterone levels, which remained suppressed for a month before returning to normal (see chart). This can cause impotence and loss of sex drive, better known as the dreaded "Deca dick." The best solution to this problem is to always use testosterone with nandrolone.

The second drug in these combination steroids is methylandrostenediol dipropionate. It is a very weak steroid with an anabolic/androgenic ratio of 30-60/20-60. No large amount of strength or muscle gain should be credited to methandriol, but it does have a few benefits that are worth mentioning. Studies show the parent hormone 5AD to promote a favorable immune system (17). This would probably prevent those who are over-trained from getting sick. Methandriol also has a binding affinity to the sites of the muscle destroying (catabolic) glucocorticoid hormones (18)blocking them from doing harm, which makes methandriol anti-catabolic. Most other profiles would tell you that methandriol somehow amplifies the muscle building potential of other steroids by "unblocking" the androgen receptor and for this reason it should be stacked with other anabolics. This statement is total garbage and should be disregarded by all Steroid.com members. Androgen receptors do not become "blocked" or "clogged up"; secondly, androgens themselves increase the numbers of androgen receptors (3), so methandriol would not be needed to do this.

So far the news on methandriol does not look good but wait, it gets worse. Methandriol's parent hormone 5AD has been shown to be a steroid with "potent estrogenic properties" (19). Since methandriol is more potent than 5AD, its estrogenic effects should cause any Steroid.com member using it grave concern. Excessive estrogenic activity can lead to gynecomastia, fat gain, water retention, loss of sex drive, and sluggish natural testosterone production. The bad news does not end there; methandriol itself binds to the estrogen receptor, needing no chemical change to exert its nasty side effects. Estrogen combined with an androgen promotes weight gain in animals better than either alone (20) however, and this is the real reason the highly estrogenic methandriol is added to other steroids, not because it "unblocks" the A.R. The "massive strength gains" allegedly from methandriol use would most likely result from the great deal of water retention inside the muscles, which would rebound when compressed during the lowering of a weight, similar to the action of a benching shirt. In addition, methandriol has also been shown to increase blood pressure (21). In fact, the only good thing about methandriol would be that it has not been shown to affect lipids, so clogged up blood vessels would be one of many sides you would not have to worry about on it. Methandriol carries di-propionate esters which are actually two propionate esters attached to the hormone.

So how could you use them in a cycle? Let's take Libriol as an example; your first problem would be the weak concentrations of hormone per ml, with 30 mg of nandrolone phenylpropionate and 40 mg of methandriol dipropionate per ml to get the recommended 400-600mg of nandrolone per week. This would mean injecting 14-20 cc per week. Adding the other injectables recommended will amount in a good deal of injection volume. This would also give you a whopping 560-800mg of the highly estrogenic methandriol. You face the same problem with Tribolan, since it contains 40mgs of MAD and 35 of nandrolone decanoate. Anabolic NA is not much better, having only 45mgs of MAD and 30mgs of Nandrolone Cypionate Per ml. If you are determined (or stupid) enough to use Libriol (or any of these combination compounds), stacking it with testosterone propionate and the anti-estrogen letrozole would be the best course of action to control the massive amount of bloat to follow. I think you'll be using about a bottle (10mls) every week if you want a real anabolic effect from Nandrolone/Methandriol. I strongly advise against using them with highly aromatizing drugs like dianabol and anadrol, and with longer acting testosterone like enanthate or cypionate. I fear the sides would be too much for the average athlete. To be honest, I would not touch Libriol with a ten-foot pole.

(Methandriol Dipropionate)

Nandrolone phenylpropionate + Methylandrostenediol Dipropionate (methandriol) blend (Trade name: Libriol, Tribolin, and Anabolic NA)
Nandrolone base + phenylpropionate ester (or Decanoate or Cypionate ester, respectively)
Formula (base): C18 H26 O2
Formula (ester): C9 H10 O2
Molecular Weight(base):274.4022
Melting Point (base): 122-124C
Manufacturer: RWR
Effective Dose (Men): 200-600mgs/week (2mg/lb of Bodyweight)
Effective Dose (Women): 50-100mgs/week
Active life: 15 days
Detection Time: Up to 18 months
Anabolic/Androgenic ratio: 125:37

Methylandrostenediol dipropionate
Formula: C20 H32 O2
Molecular Weight: 304.4716
Molecular Weight (base): 304.4716
Molecular Weight (ester): 74.0792
Formula (base): C20 H32 O2
Formula (ester): C3 H6 O2
Melting Point (ester):21.5C
Manufacturer: RWR
Effective Dose (Men):350mg week.
Effective Dose (Women): 25mg per day.
Active life: 3 days
Detection Time: 2 weeks
Anabolic/Androgenic ratio: 30-60/20-60


References:

1. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Feb 1;20(2):137-46.
2. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E483-90
3. J Appl. Physiol.94 1153-61 2003
4. Med Sci Sports Exerc. 1995 Oct;27(10):1385-9.
5. Drug hand book. 2003
6. J Vet Med A Physiol Pathol Clin Med. 2001 Aug; 48(6):343-52
7. Steriod.com forums.
8. Metabolism. 1990 Nov;39(11):1167-9
9. Am J Ther. 1998 Mar;5(2):89-95.
10. Int J Obes Relat Metab Disord. 1995 Sep; 19(9):614-24.
11. Ann Nutr Metab. 1991; 35(3):141-7.
12. Med Sci Sports Exerc. 2003 Jan; 35(1):32-8.
13. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1214-2.
14. Cancer Res 1978 Nov; 38(11 Pt 2):4186-98
15. Curr Med Res Opin. 2001;16(4):276-84
16. Pharmacol Biochem Behav. 1988 Mar; 29(3):489-93.
17. Int J Immunopharmacol. 2000 Jan;22(1):1-14.
18. Endocrinology. 1994 Mar;134(3):1401-8.
19. J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):423-32.
20. J Anim Sci. 1999 Dec;77(12):3133-9
21. Endocrinology. 1978 Jul;103(1):1-5.




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