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Nandrolone (nandrolone decanoate)

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Nandrolone is a modification of testosterone (carbon atom removed from the 19th position) With an Anabolic/Androgenic ratio: 125:37, meaning it is highly anabolic (muscle building) and moderately androgenic (male characteristics). Due to nandrolones chemical structure it only aromatizes (converts to estrogen) slightly, at about 20% the rate of testosterone when it interacts with the aromatase enzyme. Ergo, estrogenic effects are not a major concern with its use. Of note, however, is that nandrolone is a progestin with a binding affinity of 20% to the progesterone receptor (15) (PgR), so side effects are still possible, though rare. The development of breast tissue in males (gynecomastia) has been reported in some users. One of the most popular anabolic steroid used in bodybuilding cycles, nandrolone is also (medically) used to treat severe debility or disease states and refractory anemias.(1) It promotes tissue building processes, reverses catabolism (muscle destruction) and stimulates erythropoiesis (red blood cell production). This makes it a very useful drug to treat wasting disorders such as advanced H.I.V. (2)( 16), and also, makes it highly sought after by bodybuilders and athletes.


Nandrolone Decanoate, Cypionate, Laurate Cycles

Nandrolone is most commonly found with a cypionate, laurate, decanoate or plenylpropionate ester. Briefly explained, the ester determines how much of the given hormone is released over a period of time. Longer esters such as decanoate peak slowly and can keep stable blood plasma levels up to ten days, shorter esters such as the phenylpropionate peak more rapidly but the half-live is shorter. Shorter esters usually release much more active hormone per mg than longer esters, and of course, allow the drugs effects to leave your system more quickly.. Surprisingly NPP (Durabolin) and ND (Deca) release almost the same amount of active nandrolone per 100mgs: 69% and 65% respectively; this does not correlate exactly though because blood levels of nandrolone are much higher (about doubled) post NPP usage compared to the same 100mg dose of ND. (see chart) NPP also has more distinct advantages over ND. One of the most common complaints about adding ND (Deca) to a cycle is the water retention that accompanies its use. (3) Gains from NPP are reported to be "clean" with minimal water retention and fat gain. While ND is usually used in "bulking" cycles, NPP is used in "cutting" cycles although either drug can be used in either regard. Being an oil based anabolic it is injected intramuscularly (into the muscle), many users inject it ED or EOD, however NPP can administered E4D without problems.

NPP, and nandrolone in general, has a number of benefits for athletes; it increases levels of serotonergic amines in the brain, these chemicals contribute to aggressive behavior, this could help athletes to train harder and improve speed and power.4 Nandrolone also increases levels of IGF-1 in muscle tissues.(5) This may be another way that makes nandrolone highly anabolic. NPP also benefits the athlete by increasing the number of androgen receptors (AR) one study showed that nandrolone given to rats at a dosage of 6mg/kg of bodyweight combined with muscle functional overload (muscle functional overload gives a similar effect to resistance training) had a 1,300% (!) increase in AR protein concentrations. (6) There is a direct link to muscle growth and AR levels. NPP also seems to be a promising fat loss agent, men given the drug had reduced levels of subcutaneous (under skin) adipose(fat) tissue, visceral (gut) fat loss was not as good however.(7) The fat loss effect seems though to be dose dependant, in one study NPP at a daily dose of 1, 4, or 10mg per kg of bodyweight the 10mg dose had the greatest effect on fatloss, thus displaying a dose respondant curve with NPP(8). The more you use, the more results youll get, with regards to this drug.

NPP is used to treat anemia by stimulating red blood cell production,(1) and an increase in RBC count can improve endurance during exercise via better lactic acid clearing and oxygen delivery. The blood is also better enabled to carry nutrients to muscle tissue to aid in repair, administration also increases the rate of muscle glycogen repletion after exercise helping the athlete dramatically improve recovery after strenuous physical exercise.(9) Athletes who require a high level of endurance in their chosen sport can benefit from the use of NPP.(15) A favorite with bodybuilders who suffer with sore joints, NPP can also improve collagen synthesis (10), which may improve joint function and alleviate joint pains. Many members of swear by nandrolones ability to allow them to train in comfort.

Nandrolone Side Effects

Although many nandrolone lovers claim that it is one of the safest anabolic steroids, if not the safest. It does have side effects that can be bothersome in hypersensitive individuals, such as acne, excitation, insomnia, nausea, diarrhea and bladder irritability(1). More serious (and common) side effects include testicular atrophy (shrunken balls), impotence (deca dick) and gynecomastia (bitch tits) (1). Nandrolone use has been shown to be safe and easy on the lipid profile, often improving HDL Cholesterol (16) Impotence can be offset by stacking the nandrolone with a higher testosterone. Nandrolone also causes the "shut down" (total stoppage) of endogenous (natural) testosterone production. Thus an exogenous (outside) source must be provided, the increased prolactin levels from the use of a progestinic steroid contribute to HPTA shut down and testicular atrophy which can be treated with a combination HCG (a female hormone that acts like LH when introduced into the male body) and bromocriptine (a dopamine receptor agonist that, among other things, can lower prolactin levels.) (1)(11) Besides using bromcriptine to lower prolactin levels, the anti-estrogens fulvestrant or letrozole on be taken to down regulate the progesterone and estrogen receptor.(12)( 13 )

NPP can be highly useful in either "bulking" or "cutting" cycles, and it would seem that diet and dosages are the determining factors of whether a cycle with this drug will be one or the other. Due to its highly anabolic nature coupled with low androgenic properties it can be incorporated into a mass cycle, usually stacked with testosterone and a powerful oral like possibly oxymetholone (Anadrol) or methandrostenolone (Dianabol). NPP can thus be part of a classic bulking cycle. For a cutting cycle NPP is usually be combined with other short-estered injectable anabolic steroids (testosterone propionate and boldenone acetate come to mind as likely choices) and one of the DHT derived orals such as stanozolol (winstrol) or oxandrolone (Anavar). NPP is said to produce good mass and strength gains in both cutting and bulking cycle phases (3). When one is planning a cutting cycle one must take caution if combining the 19-nor-testosterone derivative trenbolone with nandrolone. Trenbolone Acetate, although a powerful drug for lean muscle gains, strength, and fat loss is also a strong progestin with a binding affinity to the PgR of 60% (3x that of nandrolone). The elevated prolactin, can worsen HPTA insult, often causing the user to spend more money on preventative measures, the combo may also result in a difficult PCT protocol to regain natural testosterone production. So far few members have any first- hand experience with NPP... limited to the few who know which UGLabs sells this particular form of nandrolone. This increases the popularity of "home brewing" ...since the powder comes out of China at very affordable prices. It is only a matter of time before NPP (or Durabolin) takes a special place in the arsenal of members in their quest for more muscle.

Nandrolone Base + Phenylpropionate Ester
    Molecular Weight(base):274.4022
    Molecular Weight (ester): 150.174
    Formula (base): C18 H26 O2
    Formula (ester): C9 H10 O2
    Melting Point (base): 122-124C
    Melting Point (ester): 20C
    Manufacturer: Organon
    Effective Dose (Men): 200-600mgs/week (2mg/lb of Bodyweight)
    Effective Dose (Women): 50-100mgs/week
    Active life: 5 days
    Detection Time: Up to 12 months
    Androgenic/Aabolic ratio: 37:125


  1. Nursing2003 drug handbook.
  2. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1214-22.
  3. forums.
  4. Med Sci Sports Exerc. 2003 Jan; 35(1):32-8.
  5. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E483-90
  6. J Appl. Physiol.94 1153-61 2003
  7. Int J Obes Relat Metab Disord. 1995 Sep; 19(9):614-24.
  8. Ann Nutr Metab. 1991; 35(3):141-7.
  9. J Vet Med A Physiol Pathol Clin Med. 2001 Aug; 48(6):343-52
  10. Metabolism. 1990 Nov; 39(11):1167-9.)
  11. Pharmacol Biochem Behav. 1988 Mar; 29(3):489-93.
  12. Cancer Res. 2003 Oct 1; 63(19):6523-31.)
  13. Expert Opin Pharmacother. 2004 Dec; 5(12):2549-58.
  14. Cancer Res 1978 Nov; 38(11 Pt 2):4186-98
  15. Med Sci Sports Exerc. 1995 Oct;27(10):1385-9.
  16. Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1214-22. Epub 2002 Aug 27.

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