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Libriol

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Libriol

Libriol is another exotic anabolic preparation coming out of Australia that is shrouded in mystery, it seems to be popular demand in bodybuilding circles because of this mystique, we will look at what are the pros and cons of this obscure drug and if it qualifies to be in the muscle building, fat-melting cycles of Steriod.com members.

Libriol is an injectable veterinary product containing short esters of the drugs nandrolone and methandriol. Steroid.com members should immediately recognize the first drug nandrolone. A steroid derived from modifying the testosterone molecule nandrolone is one of the most popular drugs in the world and with good reason, it is a versatile steroid that can be used in "bulking" or "cutting" cycles. Nandrolone has many benefits for athletes coupled with an unbeaten safety record. It has an anabolic (muscle building) ratio of 125 making it an excellent drug for adding lean muscle, it also is not very androgenic (male characteristics) with an androgenic ratio of only 37. Nandrolone aids the hardcore athlete in various ways, it promotes nitrogen retention in the muscle cell (1) which in turn promotes the muscle cell to synthesize and store more protein, nandrolone increases levels of the highly anabolic hormone IGF-1 in muscle tissue (2) the numbers of androgen receptors in muscle are also significantly increased (3). Nandrolone has been proven to improve endurance (4), increase the number of red blood cells (5) and speed the rate of glycogen replenishment after strenuous physical activity. (6) One trait Steriod.com members love nandrolone for is its ability to reduce joint pain and soreness (7), this is because the drug increases the rate of collagen synthesis and increase bone mineral content (8 9). Shown to be a good drug for fat loss (10) nandrolone can reduce the amount of fat under the skin and around the abdominal area (10) the amount lost however is dependant on dose, with higher dosages having the greatest overall effect (11) Nandrolone also has positive effects on the brain it increases chemicals in the brain that promote aggressive behavior which can improve both speed and power (12). Nandrolone aromatizes (convents to estrogen) slightly, at about 20% the rate of testosterone so estrogenic side effects such as breast tissue growth in men (gynecomastia) fat gain and water retention are not major issues. Steriod.com members who use nandrolone seldom complain of androgenic sides such as prostate enlargement, loss of hair and acne. Those who are worried about their cardio vascular health can use nandrolone without worries, studies have shown that it does not negatively affect cholesterol (13) the ester of nandrolone contained in Libriol is the phenylpropionate ester which provides a rapid, high concentration of hormone in the blood steadily for up to four days.

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Nandrolone Side Effects

Nandrolone is a good drug but it not perfect. With its chemical structure it acts directly on the receptor of the female sex hormone progesterone with a binding rate of 20% of the actual hormone (14). In gyno-prone individuals this can lead to breast growth. There is no need for panic though because the drugs letrozole(femera) or fulvestrant can easily combat this(15), elevated prolactin levels are also a side effect of nandrolone usage, bromocriptine and cabergoline are drugs that activate the dopamine receptor to lower prolactin levels(5). Shrunken balls (testicular atrophy) may be a problem from elevated prolactin as well; HCG (female hormone that acts like LH when introduced into the male body) used during the cycle can possibly remedy or prevent the condition.(16) Probably the worst effect nandrolone has is on natural testosterone production, a single 100mg dose of nandrolone causes complete shutdown of testosterone levels which remained suppressed for a month before returning to normal levels,(see chart) this can cause impotence and loss of sex drive better known as the dreaded "deca dick" the best solution to this problem is to always use testosterone with nandrolone.

The second drug in Libriol is Methylandrostenediol dipropionate. It is a very weak steroid with an anabolic/androgenic ratio of 30-60/20-60. No large amount of strength or muscle gain should be credited to methandriol it does have a few benefits that are worth mentioning however. The parent hormone 5AD in studies is shown to promote a favorable immune system (17) this would probably prevent those who are over trained from getting sick. Methandriol also has a binding affinity to the sites of the muscle destroying (catabolic) glucocorticoid hormones (18) blocking them from doing harm, this would make methandriol anti-catabolic. Most other profiles would tell you that methandriol somehow amplifies the muscle building potential of other steroids by "unblocking" the androgen receptor and for this reason it should be stacked with other anabolics, this statement is total garbage and should be disregarded by all Steroid.com members. Androgen receptors do not become "blocked" or "clogged up", secondly androgens themselves increase the numbers of androgen receptors (3) so methandriol would not be needed to do this. So far the news on methandriol does not look good but wait, it gets worse.

Methandriols parent hormone 5AD has been shown to be a steroid with "potent estrogenic properties" (19), since methandriol is more potent than 5AD, its estrogenic effects should cause any steroid.com member using it grave concern. Excessive estrogenic activity can lead to breast tissue growth in men (gynecomastia), fat gain, water retention, loss of sex drive, and sluggish natural testosterone production. The bad news does not end there; methandriol itself binds to the estrogen receptor, needing no chemical change to exert its nasty side effects. Estrogen combined with an androgen promotes weight gain in animals better than either alone (20) this is the real reason the highly estrogenic methandriol is added to other steroids not because it "unblocks" the A.R. The "massive strength gains" allegedly from methandriol use would most likely from the great deal of water retention inside the muscles which would rebound when compressed during the lowering of a weight, similar to the action of a benching shirt. Methandriol has also been shown to increase blood pressure (21) the only good thing about methandriol would be it has not been shown to affect lipids. So clogged up blood vessels would be one of many sides you would not have to worry about if you were on methandriol. Methadriol carries di-propionate esters which are actually two propionate esters attached to the hormone.

Libriol Cycle

So how would you could you use Libriol in a cycle? Your first problem would be the weak concentrations of hormone per ml, with 30 mg of nandrolone phenylpropionate and 40 mg of methandriol dipropionate per ml to get the recommended 400-600mg of nandrolone per week would mean injecting 14-20 cc per week, along with other injectables will amount in a good deal of injection volume. This would also give you a whopping 560-800mg of the highly estrogenic methandriol. If you are determined (or stupid) enough to use Libriol stacking it with testosterone propionate and the anti-estrogen letrozole would be the best course of action to control the massive amount of bloat to follow. I strongly advise against using Libriol with highly aromatizing drugs like dianabol, anadrol and longer acting testosterone like enanthate or cypionate, I fear the estrogenic sides would be too much for the athlete. To be honest I would not touch Libriol with a ten foot pole.

Nandrolone phenylpropionate + Methylandrostenediol dipropionate (methandriol) blend

Nandrolone base + phenylpropionate ester.
    Molecular Weight(base):274.4022
    Molecular Weight (ester): 150.174
    Formula (base): C18 H26 O2
    Formula (ester): C9 H10 O2
    Melting Point (base): 122-124C
    Melting Point (ester):
    Manufacturer:
    Release Date (in USA): 1962
    Effective Dose (Men): 200-600mgs/week (2mg/lb of Bodyweight)
    Effective Dose (Women): 50-100mgs/week
    Active life: 15 days
    Detection Time: Up to 18 months
    Anabolic/Androgenic ratio: 125:37

Methylandrostenediol dipropionate
    Formula: C20 H32 O2
    Molecular Weight: 304.4716
    Molecular Weight (base): 304.4716
    Molecular Weight (ester): 74.0792
    Formula (base): C20 H32 O2
    Formula (ester): C3 H6 O2
    Melting Point (base):
    Melting Point (ester):-21.5
    Manufacturer: Several Vet Cos
    Effective Dose (Men):350mg week.
    Effective Dose (Women): 25mg per day.
    Active life: 3 days
    Detection Time: 3 months
    Anabolic/Androgenic ratio: 30-60/20-60

References:

  1. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Feb 1;20(2):137-46.
  2. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E483-90
  3. J Appl. Physiol.94 1153-61 2003
  4. Med Sci Sports Exerc. 1995 Oct;27(10):1385-9.
  5. Drug hand book. 2003
  6. J Vet Med A Physiol Pathol Clin Med. 2001 Aug; 48(6):343-52. 7Steriod.com forums.
  7. Metabolism. 1990 Nov;39(11):1167-9
  8. Am J Ther. 1998 Mar;5(2):89-95.
  9. Int J Obes Relat Metab Disord. 1995 Sep; 19(9):614-24.
  10. Ann Nutr Metab. 1991; 35(3):141-7.
  11. Med Sci Sports Exerc. 2003 Jan; 35(1):32-8.
  12. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1214-2.
  13. Cancer Res 1978 Nov; 38(11 Pt 2):4186-98
  14. Curr Med Res Opin. 2001;16(4):276-84
  15. Pharmacol Biochem Behav. 1988 Mar; 29(3):489-93.
  16. Int J Immunopharmacol. 2000 Jan;22(1):1-14.
  17. Endocrinology. 1994 Mar;134(3):1401-8.
  18. J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):423-32.
  19. J Anim Sci. 1999 Dec;77(12):3133-9
  20. Endocrinology. 1978 Jul;103(1):1-5.


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